The R Journal: article published in 2010, volume 2:1

IsoGene: An R Package for Analyzing Dose-response Studies in Microarray Experiments
Setia Pramana, Dan Lin, Philippe Haldermans, Ziv Shkedy, Tobias Verbeke, Hinrich Göhlmann, An De Bondt, Willem Talloen and Luc Bijnens. , The R Journal (2010) 2:1, pages 5-12.

IsoGene is an R package for the analysis of dose-response microarray experiments to identify gene or subsets of genes with a monotone relationship between the gene expression and the doses. Several testing procedures (i.e., the likelihood ratio test, Williams, Marcus, the M, and Modified M), that take into account the order restriction of the means with respect to the increasing doses are implemented in the package. The inference is based on resampling methods, both permutations and the Significance Analysis of Microarrays (SAM).

@article{RJ-2010-001,
  author = {Setia Pramana and Dan Lin and Philippe Haldermans and Ziv
          Shkedy and Tobias Verbeke and Hinrich Göhlmann and An De
          Bondt and Willem Talloen and Luc Bijnens.},
  title = {{IsoGene: An R Package for Analyzing Dose-response Studies in
          Microarray Experiments}},
  year = {2010},
  journal = {{The R Journal}},
  doi = {10.32614/RJ-2010-001},
  url = {https://doi.org/10.32614/RJ-2010-001},
  pages = {5--12},
  volume = {2},
  number = {1}
}